![]() ![]() ![]() We performed this systematic review and meta‐analysis based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines (Moher et al., 2009), and our study protocol is submitted to PROSPERO (ID: CRD42020184456). In this systematic review and meta‐analysis, we assessed the CNS manifestations in COVID‐19 cases.Ģ.1. Therefore, awareness of the different aspects of the short‐ and long‐term effects of this virus on the central nervous system could decently guide scientists. shows the prevalence of the CNS presentations such as dizziness, headache, impaired consciousness, acute cerebrovascular disease, ataxia, and seizure (Mao et al., 2020). Furthermore, a large observational study carried out by Mao et al. Several case reports have indicated the presence of various CNS complications, including encephalitis, stroke, meningitis, and encephalopathy in COVID‐19 patients (Co et al., 2020 Filatov et al., 2020 Moriguchi et al., 2020 Zhou, Zhang, et al., 2020). However, a growing number of COVID‐19 patients are presenting with different combinations of the central nervous system (CNS) manifestations (Asadi‐Pooya & Simani, 2020 Mao et al., 2020 Montalvan et al., 2020). ![]() ![]() Most cases of COVID‐19 have shown respiratory symptoms ranging from cough to dyspnea and respiratory failure as well as the typical signs and symptoms of infection such as fever and fatigue (Cascella et al., 2020 Chen, Zhou, et al., 2020 Wang, Hu, et al., 2020 Young et al., 2020). Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a zoonotic pathogen and can transmit from infected animals (such as bats and snakes) to humans eventually leading to epidemics and pandemics through human‐to‐human transmission (Hassan et al., 2020 Mackenzie & Smith, 2020). Hence, the COVID‐19 outbreak was officially considered as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) Emergency Committee (Mackenzie & Smith, 2020 WHO, 2020). This new pandemic rapidly spread worldwide, and an increasing number of infected cases and deaths have been reported globally (Jiang et al., 2020 Sohrabi et al., 2020). At the end of December 2019, a novel respiratory syndrome, known as COVID‐19, was reported in Wuhan city, Hubei province, China. ![]()
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